新型隐球菌对多烯类和唑类药物的交叉耐药性。
Cross-resistance to polyene and azole drugs in Cryptococcus neoformans.
作者信息
Joseph-Horne T, Hollomon D, Loeffler R S, Kelly S L
机构信息
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1995 Jul;39(7):1526-9. doi: 10.1128/AAC.39.7.1526.
Abstract
Fluconazole was observed to inhibit sterol 14 alpha-demethylase in the human pathogen Cryptococcus neoformans, and accumulation of a ketosteroid product was associated with growth arrest. A novel mechanism(s) of azole and amphotericin B cross-resistance was identified, unrelated to changes in sterol biosynthesis, as previously identified in Saccharomyces cerevisiae. Reduced cellular content of drug could account for the resistance phenotype, indicating the possible involvement of a mechanism similar to multidrug resistance observed in higher eukaryotes.
摘要
观察到氟康唑可抑制人类病原体新型隐球菌中的甾醇14α-去甲基酶，一种酮类固醇产物的积累与生长停滞相关。鉴定出一种与两性霉素B交叉耐药的新机制，该机制与酿酒酵母中先前鉴定的甾醇生物合成变化无关。细胞内药物含量的降低可能是耐药表型的原因，这表明可能存在一种类似于在高等真核生物中观察到的多药耐药机制。
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