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大样本相关二元反应的两样本比较。

Two sample comparison for large groups of correlated binary responses.

作者信息

Lee E W

机构信息

Department of Environmental Medicine, New York University Medical Center, NY 10010, USA.

出版信息

Stat Med. 1996 Jun 15;15(11):1187-97. doi: 10.1002/(SICI)1097-0258(19960615)15:11<1187::AID-SIM223>3.0.CO;2-I.

Abstract

Although there is much literature on testing the treatment effect in experiments with correlated binary outcomes, the existing methodologies only work well when the cluster size is small. In this paper, I propose a simple method to test the treatment effect in experiments with large groups of correlated binary outcomes. I use the weighted estimating equations approach to estimate the treatment effect. The proposal is appropriate under any correlation structure. Power comparisons show the advantage of the new procedure.

摘要

尽管有许多关于在具有相关二元结果的实验中检验治疗效果的文献,但现有的方法仅在聚类规模较小时效果良好。在本文中,我提出了一种简单的方法来在具有大量相关二元结果的实验中检验治疗效果。我使用加权估计方程方法来估计治疗效果。该方法在任何相关结构下都是适用的。功效比较显示了新方法的优势。

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