Brownlow B S, Petro A, Feinglos M N, Surwit R S
Department of Psychology, Sarah W. Stedman Nutrition Center of Duke University, Durham, NC, USA.
Physiol Behav. 1996 Jul;60(1):37-41. doi: 10.1016/0031-9384(95)02210-4.
Previous research in our laboratory has demonstrated that the C57BL/6J (B/6J) mouse has a predisposition to develop severe obesity if placed on a high-fat diet. In the present study we assessed the role of physical activity in this phenomenon. Obesity-prone B/6J and obesity-resistant A/J mice were placed on one of four diets; high fat/high sucrose, high fat/low sucrose, low fat/high sucrose, and low fat/low sucrose. After 4 months, all animals on the high-fat diets had gained more weight than animals on the low-fat diets, and this phenomenon was greatly exaggerated in B/6J mice. Despite the fact that B/6J mice gained more weight than A/J mice on high-fat diets without consuming more calories, spontaneous motor activity was elevated in B/6J mice compared to A/J mice. There was no effect of the diets on activity either within or across strains. These data suggest that predisposition to diet-induced obesity is not explainable by reduced levels of physical activity.
我们实验室之前的研究表明，如果给C57BL/6J（B/6J）小鼠喂食高脂饮食，它们就容易患上严重肥胖症。在本研究中，我们评估了身体活动在这一现象中的作用。将易肥胖的B/6J小鼠和抗肥胖的A/J小鼠分为四组饮食之一：高脂肪/高蔗糖、高脂肪/低蔗糖、低脂肪/高蔗糖和低脂肪/低蔗糖。4个月后，所有高脂饮食组的动物比低脂饮食组的动物体重增加更多，这种现象在B/6J小鼠中更为明显。尽管在不摄入更多热量的情况下，B/6J小鼠在高脂饮食时比A/J小鼠体重增加更多，但与A/J小鼠相比，B/6J小鼠的自发运动活动有所增加。饮食对品系内或品系间的活动均无影响。这些数据表明，饮食诱导肥胖的易感性不能用身体活动水平降低来解释。
