Valenta L J, Michel-Béchet M
Cancer. 1977 Jul;40(1):284-300. doi: 10.1002/1097-0142(197707)40:1<284::aid-cncr2820400141>3.0.co;2-c.
Thirty-two thyroid tumors, 9 benign, 23 malignant, and 12 samples of normal thyroid tissue were examined by light and electron microscopy. Thyroglobulin content was also measured in the tissues and, in a limited number of cases, enzymatic activities were determined, such as thyroid peroxidase-iodinase, acid protease, and deiodinase. The presence of significant amounts of 19S, 27S and 12S thyroglobulin was well correlated with the ability of the tumors to accumulate radioiodine. It is suggested that the presence of thyroglobulin be used as a marker of potential function of thyroid carcinoma. Two types of ultrastructural changes were observed in thyroid carcinoma. The first one was interpreted as accompanying the progressive loss of function of thyroid tumors, and was represented by the modifications of highly specialized structures such as RER, lysosomal dense bodies, colloid, etc. The second one is suspected to reflect the malignant transformation of the follicular cell. This concerned namely the nuclei, mitochondria, and intracytoplasmic inclusions. These changes may have a diagnostic value since they were not observed in benign conditions.
对32个甲状腺肿瘤（9个良性、23个恶性）以及12份正常甲状腺组织样本进行了光镜和电镜检查。还测定了组织中的甲状腺球蛋白含量，并且在少数病例中测定了酶活性，如甲状腺过氧化物酶-碘化酶、酸性蛋白酶和脱碘酶。大量19S、27S和12S甲状腺球蛋白的存在与肿瘤摄取放射性碘的能力密切相关。有人提出，甲状腺球蛋白的存在可作为甲状腺癌潜在功能的标志物。在甲状腺癌中观察到两种超微结构变化。第一种变化被认为与甲状腺肿瘤功能的逐渐丧失有关，表现为高度特化结构如粗面内质网、溶酶体致密小体、胶体等的改变。第二种变化被怀疑反映了滤泡细胞的恶性转化。这主要涉及细胞核、线粒体和胞质内包涵体。这些变化可能具有诊断价值，因为在良性情况下未观察到这些变化。
