Martinez Crespo J M, Comas C, Borrell A, Puerto B, Antolin E, Ojuel J, Fortuny A
Department of Obstetrics and Gynaecology, Hospital Clinic, University of Barcelona, Spain.
Ultrasound Obstet Gynecol. 1996 Jun;7(6):447-9. doi: 10.1046/j.1469-0705.1996.07060447.x.
Doppler velocimetry of the umbilical artery was carried out during routine ultrasound examinations performed immediately before either chorionic villus sampling (n = 383) or genetic amniocentesis (n = 649) in 1032 women referred for prenatal diagnosis at our institution, between 10 and 18 weeks of gestation. Reversed end-diastolic flow was detected in only two cases (0.19%), both of which were affected by trisomy 18. The diagnosis was made at 10 weeks' gestation and, to our knowledge, these are the earliest records of this pathological Doppler pattern. Although a possible relationship with early abnormal placentation remains to be established, the finding of reversed end-diastolic velocities in the umbilical artery in the first trimester of pregnancy may be an early sign of karyotype abnormality.
在我院接受产前诊断的1032名孕妇中，于妊娠10至18周期间，在进行绒毛取样（n = 383）或羊水穿刺术（n = 649）之前立即进行的常规超声检查时，对脐动脉进行了多普勒测速。仅在两例（0.19%）中检测到舒张末期血流反向，这两例均为18三体综合征患者。诊断在妊娠10周时做出，据我们所知，这些是这种病理性多普勒模式的最早记录。尽管与早期胎盘异常的可能关系仍有待确定，但妊娠早期脐动脉舒张末期血流反向的发现可能是核型异常的早期迹象。
