从A到ζ的适体结构。

Aptamer structures from A to zeta.

作者信息

Feigon J, Dieckmann T, Smith F W

机构信息

Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, CA 90095-1569, USA.

出版信息

Chem Biol. 1996 Aug;3(8):611-7. doi: 10.1016/s1074-5521(96)90127-1.

DOI:10.1016/s1074-5521(96)90127-1

PMID:8807893

Abstract

Solution structures of RNA aptamers for FMN, ATP, arginine, and citrulline reveal how oligonucleotides can fold to form selective binding pockets for biological cofactors and amino acids. These structures confirm old ideas and provide new insights about three-dimensional structures of nucleic acids and their possible role in chemical reactions.

摘要

针对黄素单核苷酸（FMN）、三磷酸腺苷（ATP）、精氨酸和瓜氨酸的RNA适配体的溶液结构揭示了寡核苷酸如何折叠形成对生物辅因子和氨基酸具有选择性的结合口袋。这些结构证实了旧观点，并为核酸的三维结构及其在化学反应中可能发挥的作用提供了新见解。