Quintero C, Bodin L, Andersson K
Department of Physiology, National Autonomous University of Nicaragua, León.
Am J Ind Med. 1996 Jan;29(1):41-8. doi: 10.1002/(SICI)1097-0274(199601)29:1<41::AID-AJIM6>3.0.CO;2-1.
The main objective was to derive reference equations for the FVC, FEV1, and FEV1/FVC ratio for healthy Nicaraguan male workers without current occupational exposure to agents hazardous to the lungs. Age, height, and weight were included as independent variables in the analysis, but only age and height showed significant effects on the indices studied. A nonlinear relationship with age was observed for FVC and FEV1, with a shift in the slope at the age of 32 years. Linear, quadratic, and multiphase models were tested in order to assess the best reference equation. The multi-phase model most closely fitted the values measured. The FEV1/FVC ratio showed a significant linear negative correlation with age. A comparison between the equations derived from this material and those reported in other studies revealed substantial differences. Racial, genetic, nutritional, work and sociocultural factors could account for the differences.
主要目的是为未接触当前职业性肺有害物质的健康尼加拉瓜男性工人推导用力肺活量（FVC）、1秒用力呼气容积（FEV1）和FEV1/FVC比值的参考方程。年龄、身高和体重作为独立变量纳入分析，但只有年龄和身高对所研究指标有显著影响。观察到FVC和FEV1与年龄呈非线性关系，在32岁时斜率发生变化。测试了线性、二次和多阶段模型以评估最佳参考方程。多阶段模型最符合测量值。FEV1/FVC比值与年龄呈显著线性负相关。将此材料得出的方程与其他研究报告的方程进行比较，发现存在显著差异。种族、遗传、营养、工作和社会文化因素可解释这些差异。
