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Transcriptional control of human papillomavirus type 18 oncogene expression in different cell lines: role of transcription factor YY1.

作者信息

Jundt F, Herr I, Angel P, Zur Hausen H, Bauknecht T

机构信息

Forschungsschwerpunkt Angewandte Tumorvirologie, Heidelberg, Germany.

出版信息

Virus Genes. 1995;11(1):53-8. doi: 10.1007/BF01701662.

DOI:10.1007/BF01701662
PMID:8808335
Abstract

Binding of YY1 to the proximal fragment of the human papillomavirus type 18 (HPV-18) upstream regulatory region (URR) activates the oncogene expression of HPV-18 in HeLa cells, whereas in HepG2 cells this expression is repressed by YY1. In the present transient transfection study, we analyze the regulation of the HPV-18 URR by YY1 in an extended number of cell lines. Except for HeLa cells, YY1 represses or does not influence oncogene expression in all cell lines tested. In HeLa cells the activation of viral oncogene expression by YY1 is caused by the functional interplay between YY1 and a factor binding to the newly identified "switch region" of the HPV-18 URR. In this work we show that in HeLa cells, a 22 bp region located between the "switch region" and the promoter proximal fragment contributes to the modulation of the activity of YY1 and, in addition, regulates HPV-18 promoter activity independently of YY1.

摘要

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Virus Genes. 1995;11(1):53-8. doi: 10.1007/BF01701662.
2
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4
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5
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本文引用的文献

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Transcriptional control of human papillomavirus (HPV) oncogene expression: composition of the HPV type 18 upstream regulatory region.人乳头瘤病毒（HPV）癌基因表达的转录调控：18型HPV上游调控区的组成
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DNA bending and orientation-dependent function of YY1 in the c-fos promoter.YY1在c-fos启动子中的DNA弯曲及方向依赖性功能
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A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter.
Overexpression of C/EBPbeta represses human papillomavirus type 18 upstream regulatory region activity in HeLa cells by interfering with the binding of TATA-binding protein.
C/EBPβ的过表达通过干扰TATA结合蛋白的结合来抑制人乳头瘤病毒18型在HeLa细胞中的上游调控区活性。
J Virol. 1998 Mar;72(3):2113-24. doi: 10.1128/JVI.72.3.2113-2124.1998.
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A novel C/EBP beta-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region.一种新型的C/EBPβ-YY1复合物调控人乳头瘤病毒18型上游调控区的细胞类型特异性活性。
J Virol. 1996 Nov;70(11):7695-705. doi: 10.1128/JVI.70.11.7695-7705.1996.
一个转换区域决定了YY1对人乳头瘤病毒18型启动子活性的细胞类型特异性正向或负向作用。
J Virol. 1995 Jan;69(1):1-12. doi: 10.1128/JVI.69.1.1-12.1995.
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Interplay of viral and cellular proteins along the long control region of human papillomavirus type 18.人乳头瘤病毒18型长控区中病毒蛋白与细胞蛋白的相互作用
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Clusters of nuclear factor I binding sites identify enhancers of several papillomaviruses but alone are not sufficient for enhancer function.核因子I结合位点簇可识别多种乳头瘤病毒的增强子，但仅凭这些位点不足以发挥增强子功能。
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The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes.人乳头瘤病毒18型（HPV18）E2基因产物是人角质形成细胞中HPV18调控区的一种阻遏物。
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