zur Hausen H
Lancet. 1986 Aug 30;2(8505):489-91. doi: 10.1016/s0140-6736(86)90360-0.
A model is proposed to explain basic features of viral oncogenesis in man such as the long interval between primary infection and tumour appearance, the small number of infected individuals in whom cancer develops, and the monoclonality of the tumours. These cancers are viewed as the result of failing intracellular control of persisting viral genomes in proliferating cells. This type of intracellular surveillance is regarded as a defence mechanism ancestrally older than immunological control, protecting the host at cellular level against potentially lethal effects of coevolving persisting viruses.
有人提出了一个模型来解释人类病毒致癌的基本特征，比如初次感染与肿瘤出现之间的间隔时间长、发生癌症的受感染个体数量少以及肿瘤的单克隆性。这些癌症被视为增殖细胞中持续存在的病毒基因组细胞内控制失效的结果。这种细胞内监测被认为是一种比免疫控制更为古老的防御机制，在细胞水平上保护宿主免受共同进化的持续病毒的潜在致命影响。
