Parsons J D
Genome Sequencing Center, Washington University School of Medicine, St Louis, MO 63108, USA.
Comput Appl Biosci. 1995 Dec;11(6):615-9. doi: 10.1093/bioinformatics/11.6.615.
Miropeats displays DNA sequence similarity information graphically. The program discovers regions of similarity amongst any set of DNA sequences and then draws a graphic that summarizes the length, location and relative orientations of any repeated sequences. Sequence similarity searching is a very general tool that forms the basis of many different biological sequence analyses but it is limited by the verbosity of traditional alignment presentation styles. Miropeats enhances the utility of conventional DNA sequence comparisons when looking at long lengths of sequence similarity by summarizing large-scale sequence similarities on a single page of PostScript graphics. Miropeats has been applied estensively to help understand shotgun assembly projects, to check cosmid overlaps and to perform inter-genomic comparisons.
Miropeats以图形方式显示DNA序列相似性信息。该程序可发现任何一组DNA序列中的相似区域，然后绘制一幅图形，总结任何重复序列的长度、位置和相对方向。序列相似性搜索是一种非常通用的工具，是许多不同生物序列分析的基础，但它受到传统比对呈现方式冗长性的限制。当查看长片段的序列相似性时，Miropeats通过在单页PostScript图形上总结大规模序列相似性，提高了传统DNA序列比较的实用性。Miropeats已被广泛应用于帮助理解鸟枪法组装项目、检查黏粒重叠以及进行基因组间比较。
