de Gandarias J M, Irazusta J, Fernández D, Gallego M, Silió M, Casis L
Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Life Sci. 1996;59(13):1097-101. doi: 10.1016/0024-3205(96)00424-9.
Puromycin sensitive and insensitive membrane-bound aminopeptidase activity levels during the estrous cycle in several brain areas have been described in this research. We have found the highest aminopeptidase M activity levels during the proetrous stage in the hypothalamus, the amygdala and the pituitary gland. Since this enzyme has been involved in opioid peptide metabolism, it is suggested that aminopeptidase M could play a part in the decrease in the inhibitory influence of the endogenous opioids peptides that participate in the LH surge.
本研究描述了动情周期中几个脑区嘌呤霉素敏感和不敏感的膜结合氨肽酶活性水平。我们发现在发情前期下丘脑、杏仁核和垂体中氨肽酶M活性水平最高。由于该酶参与阿片肽代谢，因此提示氨肽酶M可能参与了内源性阿片肽对促黄体生成素峰抑制作用的减弱过程。
