de Gandarias J M, Irazusta J, Gil J, Fernández D, Casis L
Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Brain Res. 1993 Aug 20;620(1):146-8. doi: 10.1016/0006-8993(93)90282-r.
Brain Tyr-aminopeptidase activity levels during two stages of the rat estrous cycle (estrous and proestrous), are described in this research. The study includes the activities of the soluble and the membrane-bound forms. Soluble Tyr-aminopeptidase activity shows a significant increase during the proestrous stage in the hypothalamus. The complete membrane-bound activity did not significantly change at any point. However, a significant rise was found in the membrane-bound puromycin insensitive aminopeptidase activity in the hypothalamus and the pituitary gland during the proestrous phase.
