Smith A A, Hui F W, Crofford M J
Eur J Pharmacol. 1977 Jun 15;43(4):307-14. doi: 10.1016/0014-2999(77)90036-x.
Neonatal mice were treated with d,1-methadone, 1-alpha-acetylmethadol (LAAM) or the narcotic antagonists, naloxone, nalorphine or levallorphan. Litter mates were injected with normal saline solution and handled in the same way. Treatment began on the second postpartum day and continued daily or on alternate days for up to 6 weeks. Injection of methadone in dosages of 2 mg/kg to mg/kg inhibited weight gain in a log dose-related fashion. LAAM, 1 mg/kg or 2 mg/kg also retarded weight gain. Mice gained weight normally when naloxone, 10 mg/kg was injected with methadone, 2 mg/kg. Furthermore the daily injection of d-methadone, 4 mg/kg, did not inhibit weight gain nor did any of the narcotic antagonists. There findings indicate that growth inhibition induced by methadone is a stereospecific, opioid effect.
新生小鼠接受了右旋美沙酮、1-α-乙酰美沙醇（LAAM）或麻醉拮抗剂纳洛酮、烯丙吗啡或左洛啡烷的治疗。同窝幼鼠注射生理盐水并以相同方式处理。治疗从产后第二天开始，每天或隔天进行，持续长达6周。以2毫克/千克至毫克/千克的剂量注射美沙酮以对数剂量相关的方式抑制体重增加。1毫克/千克或2毫克/千克的LAAM也会阻碍体重增加。当10毫克/千克的纳洛酮与2毫克/千克的美沙酮一起注射时，小鼠体重正常增加。此外，每天注射4毫克/千克的右旋美沙酮既不抑制体重增加，任何一种麻醉拮抗剂也不会。这些发现表明美沙酮诱导的生长抑制是一种立体特异性的阿片样物质效应。
