Crofford M, Smith A A
Science. 1973 Sep 7;181(4103):947-9. doi: 10.1126/science.181.4103.947.
Newborn mice injected daily for 6 weeks with dl-methadone in dosages of 2 to 8 milligrams per kilogram grew significantly more slowly than their saline-treated littermates. Litters given d-methadone, 4 milligrams per kilogram, grew normally. Concomitant treatment with naloxone, 10 milligrams per kilogram, prevented growth inhibition. A weight deficit persisted in mice observed 6 weeks after cessation of methadone treatment.
新生小鼠连续6周每天注射剂量为每千克2至8毫克的消旋美沙酮，其生长速度明显慢于接受生理盐水治疗的同窝小鼠。给予每千克4毫克d-美沙酮的同窝小鼠生长正常。同时给予每千克10毫克纳洛酮可防止生长抑制。在美沙酮治疗停止6周后观察到的小鼠中，体重不足仍然存在。
