移植免疫学的双向范式。
The two-way paradigm of transplantation immunology.
作者信息
Rao A S, Starzl T E, Demetris A J, Trucco M, Thomson A, Qian S, Murase N, Fung J J
机构信息
Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
出版信息
Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 2):S46-51. doi: 10.1006/clin.1996.0141.
Abstract
The events following organ transplantation require a reciprocal cell interaction which includes both the conventional host-versus-graft reaction and a graft-versus-host component. With all successful transplantation, both graft and recipient become genetic composites. Where donors were available, chimerism has been confirmed in 30-year kidney-recipient survivors, as well as in several liver and lung recipients. A majority of liver recipients have been able to acquire an immunosuppressant-free state after 10-year survival. Animal models suggest that donor-derived cells may exert a tolerogenic effect.
摘要
器官移植后的一系列事件需要细胞间的相互作用，这既包括传统的宿主对移植物反应，也包括移植物对宿主成分。在所有成功的移植中，移植物和受体都成为了基因复合体。在有供体可用的情况下，已经在存活30年的肾移植受者以及一些肝移植和肺移植受者中证实了嵌合体的存在。大多数肝移植受者在存活10年后能够进入无免疫抑制剂状态。动物模型表明，供体来源的细胞可能发挥致耐受性作用。
相似文献
1
The two-way paradigm of transplantation immunology.移植免疫学的双向范式。
Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 2):S46-51. doi: 10.1006/clin.1996.0141.
2
Allogeneic hematopoietic cell transplantation without myeloablative conditioning for patients with advanced hematologic malignancies.对晚期血液系统恶性肿瘤患者进行非清髓性预处理的异基因造血细胞移植。
Cytotherapy. 2001;3(4):253-60. doi: 10.1080/146532401317070880.
3
iNKT cell activation plus T-cell transfer establishes complete chimerism in a murine sublethal bone marrow transplant model.iNKT 细胞活化加上 T 细胞转移在小鼠亚致死性骨髓移植模型中建立完全嵌合体。
Am J Transplant. 2018 Feb;18(2):328-340. doi: 10.1111/ajt.14453. Epub 2017 Sep 15.
4
Chimerism after organ transplantation.器官移植后的嵌合体现象。
Curr Opin Nephrol Hypertens. 1997 May;6(3):292-8. doi: 10.1097/00041552-199705000-00015.
5
The Impact of Inflammation on the Immune Responses to Transplantation: Tolerance or Rejection?炎症对移植免疫反应的影响：耐受还是排斥？
Front Immunol. 2021 Nov 22;12:667834. doi: 10.3389/fimmu.2021.667834. eCollection 2021.
6
Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation.淋巴细胞造血移植物抗宿主反应促进接受肠道移植患者的混合嵌合体形成。
J Clin Invest. 2021 Apr 15;131(8). doi: 10.1172/JCI141698.
7
Long-term tolerance to kidney allografts after induced rejection of donor hematopoietic chimerism in a preclinical canine model.临床前犬模型中诱导供者造血嵌合体排斥后的同种异体肾移植物的长期耐受。
Transplantation. 2012 Sep 27;94(6):562-8. doi: 10.1097/TP.0b013e3182646bf1.
8
Microchimerism, dendritic cell progenitors and transplantation tolerance.微嵌合体、树突状细胞祖细胞与移植耐受
Stem Cells. 1995 Nov;13(6):622-39. doi: 10.1002/stem.5530130607.
9
Adoptive immunotherapy against allogeneic kidney grafts in dogs with stable hematopoietic trichimerism.对具有稳定造血三嵌合体的犬同种异体肾移植进行过继性免疫治疗。
Biol Blood Marrow Transplant. 2008 Nov;14(11):1201-8. doi: 10.1016/j.bbmt.2008.08.005.
10
Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb.在用未成熟供体树突状细胞加抗CD40L单克隆抗体预处理的小鼠中，免疫反应性宿主细胞凋亡增加和供体白细胞嵌合率提高，而非B7分子表达的持续抑制，与心脏同种异体移植的长期存活相关。
Transplantation. 1999 Sep 27;68(6):747-57. doi: 10.1097/00007890-199909270-00006.
引用本文的文献
1
Evidence for Microchimerism in Baboon Recipients of Pig Hearts.狒狒受体猪心的微嵌合体证据。
Viruses. 2023 Jul 24;15(7):1618. doi: 10.3390/v15071618.
2
Review of the early diagnoses and assessment of rejection in vascularized composite allotransplantation.血管化复合组织异体移植排斥反应的早期诊断与评估综述。
Clin Dev Immunol. 2013;2013:402980. doi: 10.1155/2013/402980. Epub 2013 Feb 13.
3
Expression of cytokines in acute heart transplantation rejection.细胞因子在急性心脏移植排斥反应中的表达
J Huazhong Univ Sci Technolog Med Sci. 2006;26(5):583-6. doi: 10.1007/s11596-006-0527-2.
4
Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines.免疫特惠的胚胎瑞士小鼠STO及STO细胞衍生的祖细胞：主要组织相容性复合体和细胞分化抗原表达模式类似于人类胚胎干细胞系。
Immunology. 2006 Sep;119(1):98-115. doi: 10.1111/j.1365-2567.2006.02412.x. Epub 2006 Jul 10.
5
Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction.通过FasL诱导，与表达丙型肝炎病毒（HCV）结构蛋白的肝细胞共培养可增强活化的CD4+和CD8+ T细胞的凋亡。
Virology. 2006 Mar 15;346(2):363-72. doi: 10.1016/j.virol.2005.11.017. Epub 2005 Dec 5.
本文引用的文献
1
IMMUNOLOGIC STUDIES IN HUMAN ORGAN TRANSPLANTATION. I. OBSERVATION AND CHARACTERIZATION OF SUPPRESSED CUTANEOUS REACTIVITY IN UREMIA.人类器官移植中的免疫学研究。I. 尿毒症患者皮肤反应性抑制的观察与特征分析
J Exp Med. 1964 May 1;119(5):727-42. doi: 10.1084/jem.119.5.727.
2
Actively acquired tolerance of foreign cells.对外源细胞的主动获得性耐受。
Nature. 1953 Oct 3;172(4379):603-6. doi: 10.1038/172603a0.
3
Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation.肾移植术后27至29年的嵌合现象与供体特异性无反应性
Transplantation. 1993 Jun;55(6):1272-7. doi: 10.1097/00007890-199306000-00012.
4
Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance.全器官移植后的细胞迁移与嵌合现象：移植物接受的基础
Hepatology. 1993 Jun;17(6):1127-52.
5
Detection of residual host cells after bone marrow transplantation using non-isotopic in situ hybridization and karyotype analysis.
Bone Marrow Transplant. 1993 Apr;11(4):279-84.
6
Chimerism after liver transplantation for type IV glycogen storage disease and type 1 Gaucher's disease.IV型糖原贮积病和1型戈谢病肝移植后的嵌合体现象。
N Engl J Med. 1993 Mar 18;328(11):745-9. doi: 10.1056/NEJM199303183281101.
7
Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.免疫抑制药物所允许的供体细胞嵌合现象：器官移植的新视角。
Immunol Today. 1993 Jun;14(6):326-32. doi: 10.1016/0167-5699(93)90054-o.
8
Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen.利用粒细胞/巨噬细胞集落刺激因子从正常小鼠肝脏中扩增树突状细胞祖细胞及其在Ⅰ型胶原存在下的成熟发育
J Exp Med. 1994 Jun 1;179(6):1823-34. doi: 10.1084/jem.179.6.1823.
9
Murine liver allograft transplantation: tolerance and donor cell chimerism.小鼠肝脏同种异体移植：耐受性与供体细胞嵌合现象
Hepatology. 1994 Apr;19(4):916-24. doi: 10.1002/hep.1840190418.
10
Spontaneous and iatrogenically augmented leukocyte chimerism in organ transplant recipients.器官移植受者中的自发和医源性增强的白细胞嵌合现象。
Transplant Proc. 1994 Oct;26(5):3071-6.
Zotero 插件