Han J, Knops J F, Longshore J W, King P H
Laboratory of Medical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA.
Genomics. 1996 Aug 15;36(1):189-91. doi: 10.1006/geno.1996.0444.
Hel-N1 is a member of the highly conserved elav family of neuronal genes. It shares considerable sequence homology with HuD, another human member, and both genes are expressed in brain. HuD was recently mapped to chromosome 1p34. Here, we have utilized chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization to map Hel-N1 to chromosome 9p21. The different chromosomal locations of these homologous genes underscore their distinct identities.
Hel-N1是高度保守的神经元基因elav家族的成员。它与另一个人类成员HuD有相当多的序列同源性，并且这两个基因都在大脑中表达。HuD最近被定位到1号染色体的1p34区域。在这里，我们利用染色体显微切割聚合酶链反应和荧光原位杂交技术将Hel-N1定位到9号染色体的9p21区域。这些同源基因不同的染色体定位突出了它们各自的特性。
