一种参与噬菌体PRD1感染及接合宿主范围的新型质粒基因。
A novel plasmid gene involved in bacteriophage PRD1 infection and conjugative host-range.
作者信息
Holcík M, Iyer V N
机构信息
Department of Biology, Carleton University, Ottawa, Ontario, Canada.
出版信息
Plasmid. 1996 May;35(3):204-10. doi: 10.1006/plas.1996.0022.
PMID:8812786
Abstract
PRD1 infects bacteria carrying IncN plasmids by binding to their conjugative pili. Mutations in a plasmid locus kikA close to the pilus region result in PRD1 resistance and reduced conjugation proficiency to Klebsiella but not to Escherichia coli. One of the two genes of kikA is sufficient to restore both normal phenotypes. PRD1 binds to cells carrying the mutant plasmid but fails to inject its genome.
摘要
PRD1通过与携带IncN质粒的细菌的接合菌毛结合来感染这些细菌。靠近菌毛区域的质粒位点kikA发生突变会导致对PRD1产生抗性，并降低与肺炎克雷伯菌的接合效率，但对大肠杆菌则无此影响。kikA的两个基因之一就足以恢复这两种正常表型。PRD1能与携带突变质粒的细胞结合，但无法注入其基因组。
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