Behan W M, Gow J W, Simpson K, Behan P O
Department of Pathology, Glasgow University.
J Clin Pathol. 1996 Jul;49(7):592-4. doi: 10.1136/jcp.49.7.592.
Picornaviruses may not play a role as persistent agents in the inflammatory myopathies, but it is still thought likely that they may act as triggers of an autoimmune process. Forty one muscle biopsy specimens, taken from three weeks to six months (mean four months) after onset, were examined using three different picornaviral primers and PCR. Moderate to severe disease activity was evident in all specimens. The results were compared with those of 18 biopsy specimens examined later in the disease course, and with specimens from 27 patients with non-inflammatory myopathies. All results were negative. Thus, even as early as three weeks after clinical disease appears, picornaviruses are not detectable in these disorders.
微小核糖核酸病毒可能并非炎性肌病中的持续性病原体，但仍有人认为它们可能是自身免疫过程的触发因素。对41份在发病后3周-6个月（平均4个月）采集的肌肉活检标本，使用三种不同的微小核糖核酸病毒引物和聚合酶链反应进行检测。所有标本均显示出中度至重度疾病活动。将结果与疾病病程后期检测的18份活检标本以及27例非炎性肌病患者的标本进行比较。所有结果均为阴性。因此，即使在临床疾病出现后早至3周，在这些疾病中也检测不到微小核糖核酸病毒。
