Tsubota K, Toda I, Fujishima H, Yamada M, Sugawara T, Shimazaki J
Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
Br J Ophthalmol. 1994 Dec;78(12):907-11. doi: 10.1136/bjo.78.12.907.
The purpose of this study was to determine the corneal epithelial alterations induced by various types of contact lenses. By employing the specular microscope, the corneal epithelia of 60 patients who had worn contact lenses for more than 1 year were re-examined along with 15 myopic controls. The morphological changes in aphakic patients who changed from extended wear soft to extended wear rigid gas permeable lenses were also studied. The mean cell area of the corneal epithelium was 621.5 (SD 92.5) microns 2 for daily wear rigid gas permeable lenses (n = 15), 645.8 (98.1) microns 2 for daily wear soft lenses (n = 15), and 634.7 (88.6) microns 2 for extended wear rigid gas permeable lenses (n = 15), none of which differed significantly from the control value of 610.5 (98.1) microns 2. Only the extended wear soft lens group (n = 15) showed significantly enlarged epithelia (806.1 (50.1) microns 2, p < 0.01 versus the other groups). The epithelium partially returned to normal after changing from extended wear soft lenses to extended wear rigid gas permeable ones. The corneal epithelium showed increased cell area only with extended wear soft contact lenses which are known to pose a risk for corneal infection.
本研究的目的是确定各类隐形眼镜所引起的角膜上皮改变。通过使用镜面显微镜，对60名佩戴隐形眼镜超过1年的患者的角膜上皮进行了复查，并与15名近视对照者进行了比较。还研究了无晶状体患者从长期佩戴软性隐形眼镜改为长期佩戴硬性透气性隐形眼镜后的形态学变化。日戴硬性透气性隐形眼镜组（n = 15）角膜上皮的平均细胞面积为621.5（标准差92.5）平方微米，日戴软性隐形眼镜组（n = 15）为645.8（98.1）平方微米，长期佩戴硬性透气性隐形眼镜组（n = 15）为634.7（88.6）平方微米，这些均与对照组值610.5（98.1）平方微米无显著差异。只有长期佩戴软性隐形眼镜组（n = 15）显示上皮细胞显著增大（806.1（50.1）平方微米，与其他组相比p < 0.01）。从长期佩戴软性隐形眼镜改为长期佩戴硬性透气性隐形眼镜后，上皮细胞部分恢复正常。只有长期佩戴软性隐形眼镜时角膜上皮细胞面积会增加，而众所周知，长期佩戴软性隐形眼镜存在角膜感染风险。
