Speights V O, Brawn P N
Department of Pathology, Texas A&M University Health Science Center College of Medicine, Temple, USA.
Br J Urol. 1996 Mar;77(3):408-10. doi: 10.1046/j.1464-410x.1996.89315.x.
To evaluate serum prostate-specific antigen (PSA) levels in patients with granulomatous prostatitis, an inflammatory condition that can clinically mimic malignancy.
The study comprised 10 consecutive patients (age range 53-80 years) with histologically-documented granulomatous prostatitis and who had serum PSA levels recorded before and after diagnosis.
PSA levels in six of the patients were normal (< 4.0 ng/mL) at diagnosis. The other four had slightly elevated PSA levels, with three being between 4.0 and 6.0 ng/mL and the other 10.1 ng/mL. In six of the patients, there was a dramatic decrease (> 40%) in PSA level within 6-12 months after the histological documentation of granulomatous prostatitis. At the final follow-up, all 10 patients had normal PSA levels.
Granulomatous prostatitis may cause a relatively mild and transient increase in serum PSA level which resolves when the inflammation subsides.
评估肉芽肿性前列腺炎患者的血清前列腺特异性抗原（PSA）水平，这是一种在临床上可模拟恶性肿瘤的炎症性疾病。
该研究纳入了10例连续的患者（年龄范围53 - 80岁），这些患者经组织学证实患有肉芽肿性前列腺炎，且在诊断前后均记录了血清PSA水平。
6例患者在诊断时PSA水平正常（< 4.0 ng/mL）。另外4例患者的PSA水平略有升高，其中3例在4.0至6.0 ng/mL之间，另1例为10.1 ng/mL。在6例患者中，肉芽肿性前列腺炎组织学确诊后的6 - 12个月内，PSA水平显著下降（> 40%）。在最后一次随访时，所有10例患者的PSA水平均正常。
肉芽肿性前列腺炎可能导致血清PSA水平相对轻度且短暂的升高，炎症消退后该水平会恢复正常。
