威尔士吉普赛人的遗传学研究。
Genetic study of Welsh gypsies.
作者信息
Williams E M, Harper P R
出版信息
J Med Genet. 1977 Jun;14(3):172-6. doi: 10.1136/jmg.14.3.172.
Abstract
A South Wales gypsy kindred of Romany origin had a high incidence of phenylketonuria along with other recessively inherited disorders. There was a high degree of consanguinity (F = 0-017) with an excess of non-specific mental subnormality among known consanguineous matings. Phenylketonuria and a number of other recessively inherited disorders have been recorded from other Romany gypsy populations, but it is uncertain whether this results from a generally high gene frequency for the disorders or from consanguinity and other more local factors.
摘要
一个起源于罗姆人的南威尔士吉普赛家族中，苯丙酮尿症以及其他隐性遗传疾病的发病率很高。近亲结婚程度很高（F = 0.017），在已知的近亲通婚中，非特异性智力发育迟缓的情况过多。其他罗姆吉普赛人群中也记录到了苯丙酮尿症和一些其他隐性遗传疾病，但尚不确定这是由于这些疾病的基因频率普遍较高，还是由于近亲结婚及其他更局部的因素导致的。
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本文引用的文献
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The birthplaces of parents and grandparents of a series of patients with phenylketonuria in in south-east England.一系列苯丙酮尿症患者的父母及祖父母在英格兰东南部的出生地。
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Screening for inherited metabolic disease in Wales using urine-impregnated filter paper.使用浸有尿液的滤纸对威尔士的遗传性代谢疾病进行筛查。
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Anthropological significance of phenylketonuria.苯丙酮尿症的人类学意义。
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Genetic variation in Wales.威尔士的基因变异。
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