Harper P S, Williams E M, Sunderland E
J Med Genet. 1977 Jun;14(3):177-82. doi: 10.1136/jmg.14.3.177.
Data are presented on polymorphic genetic markers of 84 Welsh gypsies, members of an inbred population characterised by a high incidence of phenylketonuria and other recessively inherited diseases. Sixteen polymorphic loci were studied: the ABO blood group distribution was comparable to that of the surrounding population, the B gene frequency being 7-5%, a lower frequency than most earlier studies in gypsies. The haptoglobin 1 gene frequency (23-7%) was very different from that of the British population, resembling the frequency found in India and some previously reported gypsy groups. The data on Welsh gypsies for the various loci are discussed in relation to the known evidence for a number of European gypsy populations, and in relation to the genetic structure of these populations. It is concluded that genetic divergence has occurred in the European gypsies, and that this may have been accentuated by the dispersal, isolation, and inbreeding which have occurred during the present century.
本文呈现了84名威尔士吉普赛人的多态性基因标记数据，这些吉普赛人属于一个近亲繁殖群体，其特点是苯丙酮尿症和其他隐性遗传疾病的发病率很高。研究了16个多态位点：ABO血型分布与周围人群相当，B基因频率为7.5%，低于大多数早期对吉普赛人的研究。触珠蛋白1基因频率（23.7%）与英国人群的频率差异很大，类似于在印度和一些先前报道的吉普赛人群体中发现的频率。结合一些欧洲吉普赛人群体的已知证据以及这些群体的遗传结构，讨论了威尔士吉普赛人在各个位点的数据。得出的结论是，欧洲吉普赛人已经发生了基因分化，并且在本世纪期间发生的分散、隔离和近亲繁殖可能加剧了这种分化。
