Rueda A, Mañas M, Valverde A, Fernandez J I, Naranjo J A, Martinez-Victoria E
Departamento de Fisiología, Universidad de Granada, Spain.
Arch Physiol Biochem. 1996;104(2):246-51. doi: 10.1076/apab.104.2.246.12884.
A total of 45 preruminant goats were fed either goat milk or a milk substitute to compare the evolution of taurine and glycine conjugated bile acids and the evolution of the intestinal flora during the first month of life. Samples of hepatic bile were obtained from kids of 1, 7, 14, 21, and 28 days old and conjugated bile acids were measured by high performance liquid chromatography. Bacterial flora were determined in 14 and 28 day old animals. Ours results show that under our experimental conditions tauroconjugated bile acids clearly predominated over the conjugated with glycine. This pattern of preferential tauroconjugation persisted at all ages tested and in both groups studied. On the other hand, it seems that the quality of the protein and fat used in the elaboration of the milk replacer affects the intestinal flora and the postnatal evolution of conjugated bile acids.
总共45只反刍前山羊被喂食山羊奶或代乳品，以比较出生后第一个月内牛磺酸和甘氨酸结合胆汁酸的变化以及肠道菌群的变化。从1、7、14、21和28日龄的羔羊中获取肝胆汁样本，并通过高效液相色谱法测量结合胆汁酸。在14和28日龄的动物中测定细菌菌群。我们的结果表明，在我们的实验条件下，牛磺结合胆汁酸明显比甘氨酸结合胆汁酸占优势。这种优先牛磺结合的模式在所有测试年龄和两个研究组中都持续存在。另一方面，似乎用于配制代乳品的蛋白质和脂肪的质量会影响肠道菌群和结合胆汁酸的产后变化。
