Biswas J, Madhavan H N, Gopal L, Badrinath S S
Vision and Medical Research Foundations, Sankara Nethralaya, Madras.
Indian J Ophthalmol. 1995 Jun;43(2):63-8.
Viral retinitis is an important infectious disease of the retina which can occur in both healthy and immunocompromized or immunodeficient individuals. The clinical picture and the role of laboratory studies in diagnosis of viral retinitis are still not well-defined. We correlated the clinical picture and virologic study in the serum and vitreous specimens by Enzyme-linked Immunosorbent Assay (ELISA), rapid immunofluorescence technique and culture in five clinically suspected patients of viral retinitis. None of the patients had any evidence of systemic viral infections. In four patients, the virus was detected by immunofluorescence, ELISA or culture from the vitreous sample. Paired serum samples showed elevation of antiviral IgG titre in two cases and high antiviral IgM titre in all cases. Our study evaluated the role of virological investigations of vitreous aspirate and rising antibody titre in the paired serum samples in the diagnosis of active viral retinitis.
病毒性视网膜炎是一种重要的视网膜感染性疾病，可发生于健康人群以及免疫功能受损或免疫缺陷个体。病毒性视网膜炎的临床表现以及实验室检查在其诊断中的作用仍未明确界定。我们通过酶联免疫吸附测定（ELISA）、快速免疫荧光技术以及培养，对5例临床疑似病毒性视网膜炎患者的血清和玻璃体标本中的临床表现与病毒学研究进行了相关性分析。所有患者均无任何系统性病毒感染的证据。4例患者的玻璃体样本通过免疫荧光、ELISA或培养检测到病毒。配对血清样本显示，2例患者抗病毒IgG滴度升高，所有患者抗病毒IgM滴度均升高。我们的研究评估了玻璃体抽吸物的病毒学检查以及配对血清样本中抗体滴度升高在活动性病毒性视网膜炎诊断中的作用。
