Madhavan H N, Biswas J, Gopal L, Sharma T
Vision Research Foundation, Medical Research Foundation, Sankara Nethralaya, Madras.
Indian J Med Res. 1995 Jun;101:233-7.
Virological investigations for herpes simplex virus (HSV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) were performed in nine patients of acute retinal inflammation. Serum samples of all the patients were assayed for IgG and IgM antibodies to HSV, CMV and EBV. Vitreous fluid (VF) from 5 patients was tested by immunofluorescence and culture for detection of HSV and CMV. In four patients, VF was also assayed for IgG and IgM antibodies to HSV and CMV. HSV was shown to be the etiological agent in 3 patients with acute retinal necrosis (ARN) syndrome and in one patient with multifocal retinitis. CMV was the causative agent in one patient of ARN and 1 patient with clinically diagnosed CMV retinitis. Evidences of infection with these three viral agents could not be obtained in one patient with clinical diagnosis of CMV retinitis who tested positive for antibody to human immunodeficiency virus 1. All other patients were HIV negative. Identification of the causative viral agent of acute retinal inflammations may help an ophthalmologist to institute specific therapy particularly for HSV and CMV infections.
对9例急性视网膜炎症患者进行了单纯疱疹病毒（HSV）、巨细胞病毒（CMV）和EB病毒（EBV）的病毒学调查。检测了所有患者血清中针对HSV、CMV和EBV的IgG和IgM抗体。对5例患者的玻璃体液（VF）进行免疫荧光和培养检测，以检测HSV和CMV。在4例患者中，还检测了VF中针对HSV和CMV的IgG和IgM抗体。HSV被证明是3例急性视网膜坏死（ARN）综合征患者和1例多灶性视网膜炎患者的病原体。CMV是1例ARN患者和1例临床诊断为CMV视网膜炎患者的病原体。在1例临床诊断为CMV视网膜炎且人类免疫缺陷病毒1抗体检测呈阳性的患者中，未获得这三种病毒感染的证据。所有其他患者HIV均为阴性。确定急性视网膜炎症的致病病毒病原体可能有助于眼科医生制定特定的治疗方案，特别是针对HSV和CMV感染。
