Vinegar A, Jepson G W
Man Tech Environmental Technology, Inc., Dayton, Ohio 45437, USA.
Risk Anal. 1996 Aug;16(4):571-9. doi: 10.1111/j.1539-6924.1996.tb01102.x.
Human exposure to halons and halon replacement chemicals is often regulated on the basis of cardiac sensitization potential. The dose-response data obtained from animal testing are used to determine the no observable adverse effect level (NOAEL) and lowest observable adverse effect level (LOAEL) values. This approach alone does not provide the information necessary to evaluate the cardiac sensitization potential for the chemical of interest under a variety of exposure concentrations and durations. In order to provide a tool for decision-makers and regulators tasked with setting exposure guidelines for halon replacement chemicals, a quantitative approach was established which allowed exposures to be assessed in terms of the chemical concentrations in blood during the exposure. A physiologically-based pharmacokinetic (PBPK) model was used to simulate blood concentrations of Halon 1301 (bromotrifluoromethane, CF3Br), HFC-125 (pentafluoroethane, CHF2CF3), HFC-227ea (heptafluoropropane, CF4CHFCF3), HCFC-123 (dichlorotrifluoroethane, CHCl2CF3), and CF3I (trifluoroiodomethane) during inhalation exposures. This work demonstrates a quantitative approach for use in linking chemical inhalation exposures to the levels of chemical in blood achieved during the exposure.
人类接触哈龙和哈龙替代化学品的情况通常根据心脏致敏潜力进行管控。从动物试验获得的剂量反应数据用于确定无可见不良作用水平（NOAEL）和最低可见不良作用水平（LOAEL）值。仅靠这种方法无法提供在各种暴露浓度和持续时间下评估目标化学品心脏致敏潜力所需的信息。为了为负责制定哈龙替代化学品暴露指南的决策者和监管机构提供一种工具，建立了一种定量方法，该方法可以根据暴露期间血液中的化学物质浓度来评估暴露情况。基于生理的药代动力学（PBPK）模型用于模拟吸入暴露期间哈龙1301（溴三氟甲烷，CF3Br）、HFC - 125（五氟乙烷，CHF2CF3）、HFC - 227ea（七氟丙烷，CF4CHFCF3）、HCFC - 123（二氯三氟乙烷，CHCl2CF3）和CF3I（三氟碘甲烷）的血液浓度。这项工作展示了一种定量方法，用于将化学物质吸入暴露与暴露期间血液中化学物质的水平联系起来。
