Dodd D E, Vinegar A
ManTech Environmental Technology, Inc., Wright-Patterson Air Force Base, OH, USA.
Drug Chem Toxicol. 1998 May;21(2):137-49. doi: 10.3109/01480549809011643.
Trifluoroiodomethane (CF3I) and 1,1,2,2,3,3,3-heptafluoro-1-iodopropane (C3F7I) have been considered as replacement candidates for halon fire suppressants due to their excellent fire extinguishant capabilities and low ozone depletion potential compared to halon fire extinguishants in use currently. As part of the process to develop environmental and health effects criteria for halon substitutes, a cardiac sensitization test was conducted in beagle dogs. Cardiac sensitization to adrenaline is a phenomenon associated with the inhalation of a number of unsubstituted and halogenated hydrocarbons. Adrenaline was administered by intravenous injection before and during inhalation of the test substance. CF3I was administered to dogs at concentrations in air of 0.1, 0.2, 0.4 or 1% v/v. At each of 0.4 and 1.0% CF3I, the first dog exposed developed fatal ventricular fibrillation, and no further dogs were exposed at these concentrations. There was no cardiac sensitization at 0.1 or 0.2% CF3I. For the C3F7I experiment, dogs were exposed to concentrations in air of 0.1, 0.2 or 0.4% v/v. At each of 0.1 and 0.4% C3F7I, one dog responded with multifocal ventricular ectopic beats. Thus, CF3I and C3F7I are potent cardiac sensitizers in the adrenaline-challenged dog model.
三氟碘甲烷（CF3I）和1,1,2,2,3,3,3-七氟-1-碘丙烷（C3F7I）由于其出色的灭火能力以及与目前使用的哈龙灭火剂相比具有较低的臭氧消耗潜能，已被视为哈龙灭火剂的替代候选物。作为制定哈龙替代品环境与健康影响标准过程的一部分，在比格犬身上进行了心脏致敏试验。对肾上腺素的心脏致敏是一种与吸入多种未取代和卤代烃相关的现象。在吸入试验物质之前和期间通过静脉注射给予肾上腺素。以0.1、0.2、0.4或1%（v/v）的空气中浓度向犬给药CF3I。在CF3I浓度为0.4%和1.0%时，第一只暴露的犬发生致命性心室颤动，因此未再以这些浓度对其他犬进行暴露。在CF3I浓度为0.1%或0.2%时未出现心脏致敏现象。对于C3F7I实验，犬暴露于0.1、0.2或0.4%（v/v）的空气中浓度。在C3F7I浓度为0.1%和0.4%时，各有一只犬出现多灶性室性早搏。因此，在肾上腺素激发的犬模型中，CF3I和C3F7I是强效心脏致敏剂。
