α2肾上腺素能受体拮抗剂育亨宾对正常受试者生长激素对阿扑吗啡反应的影响。
The effect of Yohimbine, an alpha2 adrenergic receptor antagonist, on the growth hormone response to apomorphine in normal subjects.
作者信息
Lal S, Thavundayil J X, Krishnan B, Nair N P, Schwartz G, Guyda H
机构信息
Douglas Hospital Research Centre, Verdun, Quebec, Canada.
出版信息
J Psychiatry Neurosci. 1996 Mar;21(2):96-100.
Abstract
Yohimbine HCl (16 mg po) administered 30 min before clonidine (CLON) (2 ug/kg infused over 10 min) (N = 5) or apomorphine HCl (Apo) (0.5 mg sc) (N = 10) antagonized the growth hormone (GH) response to CLON but had no effect on the GH response to Apo in normal men. This finding suggests that in humans, alpha2 adrenergic mechanisms do not modulate dopaminergic function, at least not in the hypothalamic-pituitary axis, and that the GH response to Apo is not mediated via an alpha2 adrenergic link.
摘要
盐酸育亨宾（口服16毫克）在可乐定（CLON）（10分钟内静脉注射2微克/千克）（N = 5）或盐酸阿扑吗啡（Apo）（皮下注射0.5毫克）（N = 10）前30分钟给药，可拮抗正常男性对可乐定的生长激素（GH）反应，但对阿扑吗啡的GH反应无影响。这一发现表明，在人类中，α2肾上腺素能机制并不调节多巴胺能功能，至少在下丘脑-垂体轴中不调节，并且对阿扑吗啡的GH反应不是通过α2肾上腺素能联系介导的。
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