CCK - 8可拮抗正常受试者中阿扑吗啡诱导的生长激素分泌。
CCK-8 antagonizes apomorphine-induced growth hormone secretion in normal subjects.
作者信息
Nair N P, Lal S, Eugenio H, Lizondo E, Thavundayil J X, Wood P L, Etienne P, Guyda H
出版信息
Horm Metab Res. 1986 Jan;18(1):53-5. doi: 10.1055/s-2007-1012224.
Cholecystokinin octapeptide (CCK-8) (5 ug iv over 10 minutes) administered to normal men had no effect on basal growth hormone (GH) or prolactin secretion but significantly antagonized the GH response to the dopamine (DA) receptor agonist, apomorphine HCI (Apo) (0.5 mg sc), 30 (P less than 0.05) and 45 minutes (P less than 0.01) after Apo injection (n = 8). These results are compatible with an inhibitory effect of CCK-8 on certain DA mechanisms in the hypothalamic-pituitary axis. Whether CCK-8 affects DA function in other brain regions in man is unknown.
向正常男性静脉注射八肽胆囊收缩素（CCK - 8）（10分钟内注射5微克）对基础生长激素（GH）或催乳素分泌无影响，但能显著拮抗生长激素对多巴胺（DA）受体激动剂盐酸阿扑吗啡（Apo）（皮下注射0.5毫克）注射后30分钟（P < 0.05）和45分钟（P < 0.01）时的反应（n = 8）。这些结果与CCK - 8对下丘脑 - 垂体轴某些多巴胺机制的抑制作用相符。CCK - 8是否影响人类其他脑区的多巴胺功能尚不清楚。
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