非典型抗精神病药物舒必利对阿扑吗啡诱导的生长激素分泌的影响。
Effect of sulpiride, an atypical neuroleptic, on apomorphine-induced growth hormone secretion.
作者信息
Nair N P, Lal S, Iskandar H I, Etienne P, Wood P L, Guyda H
出版信息
Brain Res Bull. 1982 Jun;8(6):587-91. doi: 10.1016/0361-9230(82)90085-5.
PMID:7139355
Abstract
Sulpiride (100 mg IM), an atypical neuroleptic, which does not block dopamine (DA) receptors that are linked to adenylate cyclase, abolished the growth hormone (GH) response to the DA receptor agonist, apomorphine (Apo) HCl (0.5 mg SC) in seven healthy male subjects. These results suggest that Apo increases GH secretion in man by an effect on DA receptors that are not linked to adenylate cyclase.
摘要
舒必利（100毫克，肌肉注射），一种非典型抗精神病药物，它不阻断与腺苷酸环化酶相连的多巴胺（DA）受体，在7名健康男性受试者中消除了生长激素（GH）对DA受体激动剂盐酸阿扑吗啡（Apo，0.5毫克，皮下注射）的反应。这些结果表明，阿扑吗啡通过作用于与腺苷酸环化酶不相连的DA受体来增加人体生长激素的分泌。
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