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一种用于致病性大分子输出的接合转移系统的改造

Adaptation of a conjugal transfer system for the export of pathogenic macromolecules.

作者信息

Winans S C, Burns D L, Christie P J

机构信息

Section of Microbiology, Cornell University, Ithaca, NY 14853, USA.

出版信息

Trends Microbiol. 1996 Feb;4(2):64-8. doi: 10.1016/0966-842X(96)81513-7.

DOI:10.1016/0966-842X(96)81513-7
PMID:8820569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4848025/
Abstract

Conjugal transfer of bacterial plasmids requires a pore through which DNA can traverse the envelopes of the donor and recipient cells. Recent studies indicate that these pores, which are composed of approximately ten proteins, are evolutionarily related to the transport systems required for the transfer of oncogenic T-DNA from Agrobacterium tumefaciens to plant cells and for toxin secretion from Bordetella pertussis.

摘要

细菌质粒的接合转移需要一个孔道,DNA可通过该孔道穿过供体细胞和受体细胞的包膜。最近的研究表明,这些孔道由大约十种蛋白质组成,在进化上与致癌性Ti质粒从根癌土壤杆菌转移至植物细胞以及百日咳博德特氏菌分泌毒素所需的转运系统相关。

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本文引用的文献

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Conjugative Transfer by the Virulence System of Agrobacterium tumefaciens.农杆菌毒力系统的共轭转移。
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Molecular characterization of an operon required for pertussis toxin secretion.百日咳毒素分泌所需操纵子的分子特征分析。
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Subcellular localization of seven VirB proteins of Agrobacterium tumefaciens: implications for the formation of a T-DNA transport structure.根癌土壤杆菌七种VirB蛋白的亚细胞定位:对T-DNA转运结构形成的影响
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Molecular cloning and characterization of 13 out genes from Erwinia carotovora subspecies carotovora: genes encoding members of a general secretion pathway (GSP) widespread in gram-negative bacteria.胡萝卜软腐欧文氏菌胡萝卜软腐亚种13个外排基因的分子克隆与特性分析:编码在革兰氏阴性菌中广泛存在的一般分泌途径(GSP)成员的基因
Mol Microbiol. 1993 May;8(3):443-56. doi: 10.1111/j.1365-2958.1993.tb01589.x.
7
Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon.百日咳毒素的输出需要位于百日咳毒素操纵子下游的辅助基因。
Mol Microbiol. 1993 May;8(3):429-34. doi: 10.1111/j.1365-2958.1993.tb01587.x.
8
Site-specific cleavage and joining of single-stranded DNA by VirD2 protein of Agrobacterium tumefaciens Ti plasmids: analogy to bacterial conjugation.根癌土壤杆菌Ti质粒的VirD2蛋白对单链DNA的位点特异性切割与连接:与细菌接合的类比
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11538-42. doi: 10.1073/pnas.90.24.11538.
9
Genetic complementation analysis of the Agrobacterium tumefaciens virB operon: virB2 through virB11 are essential virulence genes.根癌土壤杆菌virB操纵子的遗传互补分析:virB2至virB11是必需的毒力基因。
J Bacteriol. 1994 Jun;176(12):3646-60. doi: 10.1128/jb.176.12.3646-3660.1994.
10
An inner-membrane-associated virulence protein essential for T-DNA transfer from Agrobacterium tumefaciens to plants exhibits ATPase activity and similarities to conjugative transfer genes.一种对根癌农杆菌向植物转移T-DNA至关重要的内膜相关毒力蛋白具有ATP酶活性,且与接合转移基因相似。
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