一种用于致病性大分子输出的接合转移系统的改造
Adaptation of a conjugal transfer system for the export of pathogenic macromolecules.
作者信息
Winans S C, Burns D L, Christie P J
机构信息
Section of Microbiology, Cornell University, Ithaca, NY 14853, USA.
出版信息
Trends Microbiol. 1996 Feb;4(2):64-8. doi: 10.1016/0966-842X(96)81513-7.
Abstract
Conjugal transfer of bacterial plasmids requires a pore through which DNA can traverse the envelopes of the donor and recipient cells. Recent studies indicate that these pores, which are composed of approximately ten proteins, are evolutionarily related to the transport systems required for the transfer of oncogenic T-DNA from Agrobacterium tumefaciens to plant cells and for toxin secretion from Bordetella pertussis.
摘要
细菌质粒的接合转移需要一个孔道，DNA可通过该孔道穿过供体细胞和受体细胞的包膜。最近的研究表明，这些孔道由大约十种蛋白质组成，在进化上与致癌性Ti质粒从根癌土壤杆菌转移至植物细胞以及百日咳博德特氏菌分泌毒素所需的转运系统相关。
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Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon.百日咳毒素的输出需要位于百日咳毒素操纵子下游的辅助基因。
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