Fischer P A
Neurological Clinic, J.W.G. University, Frankfurt/M., Federal Republic of Germany.
J Neural Transm Suppl. 1995;46:381-9.
Parkinson's disease is treated in relation to its symptoms and stage in any individual plan of therapy. L-Dopa treatment is the most effective method of therapy and there is no evidence that would prohibit the early application of L-Dopa. The side-effects and motor complications during long-term L-Dopa treatment have led to give preference to combinations of L-Dopa with other anti-Parkinsonian agents. It is still controversial as to which combination of agents sould be used and whether L-Dopa long-term problems demand the initial introduction of a combination therapy. Another open question is whether neuroprotection is possible in Parkinson's disease with the drugs currently available. In advanced stages of Parkinson's disease treatment of concomitand mental symptoms and multifarious disorders of the autonomic nervous system are becoming of increasing significance.
帕金森病的治疗是根据其症状和阶段在任何个体治疗方案中进行的。左旋多巴治疗是最有效的治疗方法，并且没有证据表明应禁止早期应用左旋多巴。长期左旋多巴治疗期间的副作用和运动并发症导致人们更倾向于使用左旋多巴与其他抗帕金森病药物的联合用药。关于应使用哪种药物组合以及左旋多巴的长期问题是否需要初始引入联合治疗仍存在争议。另一个未解决的问题是，使用目前可用的药物在帕金森病中是否可能实现神经保护。在帕金森病的晚期，伴随的精神症状和自主神经系统的多种紊乱的治疗变得越来越重要。
