Lange K W, Tucha O, Steup A, Gsell W, Naumann M
Department of Neuropsychology and Research Programme in Neuropsychology and Neurolinguistics, University of Freiburg, Federal Republic of Germany.
J Neural Transm Suppl. 1995;46:433-8.
Patients with idiopathic Parkinson's disease and control subjects were given two types of time estimation task. In the verbal estimation task subjects were required to judge the duration of time intervals of 10, 30 and 60 seconds, signalled by the examiner. Operative estimation required subjects to indicate when intervals of 10, 30 and 60 seconds had passed. Parkinsonian patients off L-Dopa medication were less accurate than control subjects in both tasks. They underestimated the time intervals determined by the examiner in the verbal estimation task, while in the operative estimation task parkinsonian subjects overestimated the required time intervals compared with controls. The administration of L-Dopa to the parkinsonian patients led to time judgements that were similar to those of control subjects. The present findings lend support to the hypothesis of the role of dopamine in the modulation of the internal clock.
特发性帕金森病患者和对照受试者接受了两种类型的时间估计任务。在言语估计任务中，受试者需要判断由检查者发出信号的10秒、30秒和60秒时间间隔的持续时间。操作估计要求受试者指出10秒、30秒和60秒的时间间隔何时过去。未服用左旋多巴药物的帕金森病患者在两项任务中的准确性均低于对照受试者。在言语估计任务中，他们低估了检查者确定的时间间隔，而在操作估计任务中，与对照组相比，帕金森病受试者高估了所需的时间间隔。给帕金森病患者服用左旋多巴导致时间判断与对照受试者相似。目前的研究结果支持多巴胺在调节内部时钟中作用的假说。
