Le Jan C
Unité de pathologie infectieuse et immunologie, Inra, Nouzilly, France.
Vet Res. 1996;27(4-5):403-17.
Mammary secretions contain viable maternal cells that are mainly lymphocytes, macrophages, neutrophils and epithelial cells. Their biological functions in the neonate, though not yet clearly established, are strongly suggested by experimental data. This paper reviews current knowledge of the cellular components of mammary secretions: their nature, in vitro properties, and demonstrated in vivo effects in the neonate, and discusses possible future experimental approaches. It is thought that the main role of the cellular components from mammary secretions is to interact with the development of local immunity in the newborn, and to modulate active immunization of the neonatal intestine during this critical period when the development of adapted responses to antigens (protection/tolerance/alimentary allergy) is of crucial importance for the future of the young.
乳腺分泌物含有活的母体细胞，主要是淋巴细胞、巨噬细胞、中性粒细胞和上皮细胞。尽管它们在新生儿中的生物学功能尚未明确，但实验数据有力地表明了这些功能。本文综述了目前关于乳腺分泌物细胞成分的知识：它们的性质、体外特性以及在新生儿体内已证实的作用，并讨论了未来可能的实验方法。人们认为，乳腺分泌物细胞成分的主要作用是与新生儿局部免疫的发育相互作用，并在这一关键时期调节新生儿肠道的主动免疫，此时对抗原的适应性反应（保护/耐受/食物过敏）的发育对幼崽的未来至关重要。
