Parmely M J, Beer A E
J Dairy Sci. 1977 Apr;60(4):655-65. doi: 10.3168/jds.S0022-0302(77)83915-5.
Historically colostrum and milk have been thought to confer immunity on the neonate only by virtue of their immunoglobulin content. Recently we have observed that colostrum also contains viable T lymphocytes capable of expressing cell-mediated immunity in vitro and have employed techniques of lymphocyte culture to elucidate the local nature of mammary tissue immunity at the T-cell level. The results indicate that the activity of colostral lymphocytes appears not to represent the total immunological experience of the mother but that they may contain reactive clones beneficial for the suckling. Colostral immunity appears to depend upon sensitizing events within the intestine and respiratory tract, followed by the migration of lymphoid precursors to the breast, suggesting a relationship between the expression of immunity at various secretory surfaces.
从历史上看，初乳和乳汁一直被认为仅通过其免疫球蛋白含量赋予新生儿免疫力。最近，我们观察到初乳还含有能够在体外表达细胞介导免疫的活T淋巴细胞，并采用淋巴细胞培养技术来阐明乳腺组织免疫在T细胞水平上的局部性质。结果表明，初乳淋巴细胞的活性似乎并不代表母亲的全部免疫经历，但它们可能含有对哺乳有益的反应性克隆。初乳免疫似乎取决于肠道和呼吸道内的致敏事件，随后淋巴样前体细胞迁移至乳腺，这表明不同分泌表面的免疫表达之间存在关联。
