Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Department of Hemostasis and Hemostatic Disorders, Faculty of Health Sciences, Medical University of Lodz, Lodz, Poland.
Adv Nutr. 2021 Mar 31;12(2):533-545. doi: 10.1093/advances/nmaa120.
Inflammatory bowel disease (IBD) is a group of chronic relapsing disorders whose etiology has not been fully explained. Therefore, available therapeutic approaches for IBD patients are still insufficient. Current treatment strategies are targeted to immune system dysfunctions, often associated with alternations in the microbiota, which contribute to the development of chronic intestinal inflammation. Therapeutics include anti-inflammatory drugs such as aminosalicylates and corticosteroids, immunosuppressive agents, antibiotics, and biological agents such as infliximab and vedolizumab. Auxiliary therapies involve a balanced and personalized diet, healthy lifestyle, avoiding stress, as well as dietary supplements. In this review, we discuss the use of bovine colostrum (BC) as a therapeutic agent, including its advantages and contraindications. We summarize our knowledge on well-researched BC constituents and their effects on the gastrointestinal tract as evidenced in in vitro and in vivo studies.
炎症性肠病（IBD）是一组慢性复发性疾病，其病因尚未完全阐明。因此，目前针对 IBD 患者的治疗方法仍然不足。目前的治疗策略针对免疫系统功能障碍，通常与微生物群的改变有关，这些改变有助于慢性肠道炎症的发展。治疗方法包括氨基水杨酸盐和皮质类固醇等抗炎药物、免疫抑制剂、抗生素和生物制剂，如英夫利昔单抗和维得利珠单抗。辅助疗法包括均衡和个性化的饮食、健康的生活方式、避免压力以及膳食补充剂。在这篇综述中，我们讨论了牛初乳（BC）作为治疗剂的使用，包括其优点和禁忌症。我们总结了我们对经过充分研究的 BC 成分及其对胃肠道的影响的了解，这些影响在体外和体内研究中得到了证实。
