Kotilainen P, Merilahti-Palo R, Lehtonen O P, Manner I, Helander I, Möttönen T, Rintala E
Department of Medicine, Turku University Central Hospital, Finland.
J Rheumatol. 1996 Jul;23(7):1302-4.
A woman presented with palmar pustulosis and deep chest pain in association with osteitic lesions in the lower part of the sternum. Propionibacterium acnes was isolated and grew in pure culture from 6 surgically obtained bone specimens. The patient received clindamycin treatment for 6 months. Synovitis in both her wrists persisted and, based on a clinical suspicion of seronegative rheumatoid arthritis, she was treated with intramuscular gold and methotrexate with no apparent benefit. Subsequently, she was diagnosed with SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteomyelitis). Our patient provides further data on the potential association between P. acnes and SAPHO syndrome.
一名女性患者出现掌跖脓疱病并伴有胸骨下部骨炎病变引起的深部胸痛。从6份手术获取的骨标本中分离出痤疮丙酸杆菌并进行了纯培养。患者接受了6个月的克林霉素治疗。她双腕的滑膜炎持续存在，基于血清阴性类风湿关节炎的临床怀疑，她接受了肌肉注射金制剂和甲氨蝶呤治疗，但无明显效果。随后，她被诊断为SAPHO综合征（滑膜炎、痤疮、脓疱病、骨肥厚和骨髓炎）。我们的患者为痤疮丙酸杆菌与SAPHO综合征之间的潜在关联提供了进一步的数据。
