Batliwalla F, Monteiro J, Serrano D, Gregersen P K
Division of Biology and Human Genetics, North Shore University Hospital/Cornell University Medical College, Manhasset, New York 11030, USA.
Hum Immunol. 1996 Jun-Jul;48(1-2):68-76. doi: 10.1016/0198-8859(96)00077-8.
Oligoclonality of the CD8+ T cell subset is a common and characteristic feature of the normal human peripheral T cell repertoire. These clonally expanded populations are predominantly found in a CD57+ or CD28- CD8+ T cell subset. While CD8 oligoclonality is somewhat more common in the older age group, it is also very prevalent in young to middle-aged adults. Recent experiments have also demonstrated that the clonally expanded populations may actually occur in two distinct subpopulations of CD8+ CD28- cells, distinguished by the expression of the CD57 surface marker. A major difficulty with studies involving CD8+ CD28- CD57+ T cells is their relative lack of proliferative capacity. We have recently investigated the possibility that this phenotype may be due to a state of "replicative senescence" in some cases. In this regard, we have demonstrated that the telomere lengths of CD8+ CD28- T cells are generally shorter than that of their CD8+ CD28+ counterparts, consistent with a distinct replicative history for the CD8+ CD28- population. Additional studies of the normal biology of clonally expanded CD8+ T cells are likely to yield important insights into immune function in health and disease.
CD8+ T细胞亚群的寡克隆性是正常人类外周T细胞库的一个常见且特征性的特点。这些克隆性扩增的群体主要存在于CD57+或CD28-CD8+ T细胞亚群中。虽然CD8寡克隆性在老年人群体中更为常见，但在年轻至中年成年人中也非常普遍。最近的实验还表明，克隆性扩增的群体实际上可能出现在CD8+ CD28-细胞的两个不同亚群中，这两个亚群通过CD57表面标志物的表达来区分。涉及CD8+ CD28- CD57+ T细胞的研究的一个主要困难是它们相对缺乏增殖能力。我们最近研究了这种表型在某些情况下可能是由于“复制性衰老”状态的可能性。在这方面，我们已经证明CD8+ CD28- T细胞的端粒长度通常比其CD8+ CD28+对应细胞的端粒长度短，这与CD8+ CD28-群体独特的复制历史一致。对克隆性扩增的CD8+ T细胞正常生物学的进一步研究可能会对健康和疾病中的免疫功能产生重要见解。
