Di Santo J P, Kühn R, Müller W
INSERM U429, Hôpital Necker-Enfants Malades, Paris, France.
Immunol Rev. 1995 Dec;148:19-34. doi: 10.1111/j.1600-065x.1995.tb00091.x.
The common cytokine receptor gamma chain (gamma c) plays a critical role in lymphoid development through its participation in the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Absence of gamma c results in abnormal lymphopoiesis and immunodeficiency, as evidence by X-linked severe combined immunodeficiency (SCIDX1) in man, and in the corresponding canine and murine models of SCIDX1. Comparison of the phenotypes of mutant mice made deficient for gamma c-dependent cytokines by gene targeting, allows us to define a hierarchy of gamma c-dependent cytokine function in lymphoid development. The participation of distinct cytokine/receptor interactions in the generation, maintenance and regulation of the immune system suggests that developmental steps may be controlled by individual cytokines. The mechanisms by which different cytokine signaling pathways achieve this process remain to be elucidated.
常见细胞因子受体γ链（γc）通过参与白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、白细胞介素-7（IL-7）、白细胞介素-9（IL-9）和白细胞介素-15的受体，在淋巴细胞发育中起关键作用。γc的缺失会导致异常的淋巴细胞生成和免疫缺陷，这在人类的X连锁严重联合免疫缺陷病（SCIDX1）以及相应的犬类和鼠类SCIDX1模型中得到了证实。通过基因靶向使依赖γc的细胞因子缺失的突变小鼠的表型比较，使我们能够确定γc依赖的细胞因子在淋巴细胞发育中的功能层次。不同细胞因子/受体相互作用在免疫系统的产生、维持和调节中的参与表明，发育步骤可能由单个细胞因子控制。不同细胞因子信号通路实现这一过程的机制仍有待阐明。
