He Y W, Malek T R
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33136, USA.
Crit Rev Immunol. 1998;18(6):503-24. doi: 10.1615/critrevimmunol.v18.i6.20.
Five cytokines, IL-2, IL-4, IL-7, IL-9, and IL-15, form one group that is characterized by utilizing the common gamma chain (gamma c) as a receptor subunit. Examination of the phenotype of various cytokine or cytokine receptor "knockout" mice demonstrates that these cytokines are critical for normal lymphocyte development and subsequent functional activity of the peripheral immune compartment. This review summarizes the structural and functional properties of each of these five cytokines and their receptors, including the known redundant pathways for each cytokine or receptor. The contribution of these cytokines and receptors will then be considered in detail with respect to regulation of T lymphocyte development and homeostasis of the peripheral T cell compartment.
白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、白细胞介素-7（IL-7）、白细胞介素-9（IL-9）和白细胞介素-15（IL-15）这五种细胞因子形成一组，其特征是利用共同的γ链（γc）作为受体亚基。对各种细胞因子或细胞因子受体“敲除”小鼠的表型进行检查表明，这些细胞因子对于正常淋巴细胞发育以及外周免疫区室随后的功能活性至关重要。本综述总结了这五种细胞因子及其受体各自的结构和功能特性，包括每种细胞因子或受体已知的冗余途径。然后将详细探讨这些细胞因子和受体在T淋巴细胞发育调节和外周T细胞区室稳态方面的作用。
