Farkas R, Hall M J, Dániel M, Börzsönyi L
University of Veterinary Science, Budapest, Hungary.
Parasitol Res. 1996;82(1):82-6. doi: 10.1007/s004360050073.
The therapeutic efficacies of ivermectin (Ivomec injection, Merck Sharp & Dohme B.V.) and moxidectin (Cydectin 1% injection, American Cyanamid Company) were evaluated in sheep naturally infested with larvae of Wohlfahrtia magnifica. Sheep were randomly allocated to one of the 2 groups, each consisting of 19 animals. Sheep in one group received ivermectin and those in the other, moxidectin by subcutaneous injection at a dose of 0.2 mg/kg body weight. Evaluation was performed at 19, 24, 28, 39, 43, 48, 52, 63, 67, 72, 87, 96, 120, 144 and 168 h after treatment. At 144 and 168 h post-treatment, late third-instar larvae were collected from wounds of four sheep in both groups and from untreated, infested sheep. These larvae were reared in the laboratory to assess adult emergence. Neither ivermectin nor moxidectin was effective as a rapid acting treatment or as a long-term, or even short-term, prophylactic. Despite the treatment, 30-40% of sheep had live larvae at every evaluation. Although larvae disappeared from the wounds of some sheep in both groups after the treatment, the wounds in these animals failed to recover and were reinfested by larvae of W. magnifica. On day 7 post-treatment the trial had to be finished because the majority of treated sheep were severely infested by Wohlfahrtia maggots. The average number of infested sheep in the two groups and the number of adults that were produced from larvae collected from treated sheep indicate that ivermectin and moxidectin did not differ significantly in efficacy.
在自然感染了丽蝇蛆（Wohlfahrtia magnifica）幼虫的绵羊中评估了伊维菌素（伊维菌素注射液，默克雪兰诺有限公司）和莫昔克丁（赛得菌素1%注射液，美国氰胺公司）的治疗效果。绵羊被随机分为2组，每组19只动物。一组绵羊接受伊维菌素治疗，另一组接受莫昔克丁治疗，均通过皮下注射，剂量为0.2 mg/kg体重。在治疗后19、24、28、39、43、48、52、63、67、72、87、96、120、144和168小时进行评估。在治疗后144和168小时，从两组的四只绵羊的伤口以及未治疗的感染绵羊的伤口中收集晚期三龄幼虫。将这些幼虫在实验室中饲养以评估成虫羽化情况。伊维菌素和莫昔克丁作为快速起效的治疗方法或作为长期甚至短期的预防措施均无效。尽管进行了治疗，但每次评估时仍有30 - 40%的绵羊体内有活幼虫。虽然两组中一些绵羊伤口处的幼虫在治疗后消失了，但这些动物的伤口未能愈合，并且再次被丽蝇蛆幼虫感染。治疗后第7天，试验不得不结束，因为大多数接受治疗的绵羊被丽蝇蛆严重感染。两组中受感染绵羊的平均数量以及从接受治疗的绵羊收集的幼虫发育而成的成虫数量表明，伊维菌素和莫昔克丁在疗效上没有显著差异。
