一个大型多中心癌症家族与BRCA2相关。
A large multisite cancer family is linked to BRCA2.
作者信息
Tonin P, Ghadirian P, Phelan C, Lenoir G M, Lynch H T, Letendre F, Belanger D, Monté M, Narod S A
机构信息
Department of Medicine, McGill University, Montreal, Quebec, Canada.
出版信息
J Med Genet. 1995 Dec;32(12):982-4. doi: 10.1136/jmg.32.12.982.
We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod = 3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.
我们鉴定出一个法裔加拿大家庭，其中有21例乳腺癌患者，包括两名患病兄弟。对该家族13号染色体q臂上标记物的分离分析表明，其与BRCA2基因座存在连锁关系（在D13S289处的连锁值为3.67）。该家族还出现了一些其他类型的癌症，包括3例前列腺癌和2例淋巴瘤。据估计，BRCA2基因携带者中乳腺癌的发病风险至70岁时为75%。
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