Becker H, Hottenrott C, Seufert R M, Gerstenbergk L
Res Exp Med (Berl). 1977 Jun 29;170(2):125-31. doi: 10.1007/BF01851383.
In 74 immature pigs a hemorrhagic shock (3 hrs duration: mean arterial pressure 40 mm Hg) was established (NORTON 1972). Following this systemic stress all animals developed stress-lesions of stomach and duodenum. In comparison to other stress-models porcine hemorrhagic shock seems to be qualified to study pathogenesis, prophylaxis and therapy of gastric stress-lesions: Pigs correspond best to humans in their gastro-intestinal physiology, hypotension simulates one of the most important surgical causes of stress complications and stress-lesion produced by this model have a marked similarity to those of humans. In contrast to these advantages there are some problems in using this model: Prompt and dangerous electrolyte imbalance following correction of disturbances in acid base equilibrium; irreversible shock following protracted hypotension (3 hrs). For this reason 19% of all piglets died before (1 animal), during (10 animals) or immediately after shock (3 animals). By careful observation of the mentioned problems, however, this experimental model combines a high incidence of stress-lesions with a low rate of casualities.
在74只未成年猪身上建立了失血性休克模型（持续3小时，平均动脉压40毫米汞柱）（诺顿，1972年）。经历这种全身性应激后，所有动物都出现了胃和十二指肠的应激性损伤。与其他应激模型相比，猪失血性休克似乎适合用于研究胃应激性损伤的发病机制、预防和治疗：猪在胃肠生理学方面与人类最为相似，低血压模拟了应激并发症最重要的手术病因之一，且该模型产生的应激性损伤与人类的应激性损伤有显著相似性。与这些优点相反，使用该模型存在一些问题：纠正酸碱平衡紊乱后会迅速出现危险的电解质失衡；长时间低血压（3小时）后会出现不可逆休克。因此，在所有仔猪中，有19%在休克前（1只动物）、休克期间（10只动物）或休克后立即（3只动物）死亡。然而，通过仔细观察上述问题，该实验模型在应激性损伤高发的同时，死亡率较低。
