Hottenrott C, Seufert R M, Kühne F W, Büsing M
Ann Surg. 1977 Dec;186(6):762-5. doi: 10.1097/00000658-197712000-00019.
Fifteen mini-pigs were bled to a mean aortic blood pressure of 40 mm Hg and maintained at that level for three hours. The control group consisted of eight animals with shock for three hours, while the test group was comprised of seven animals with a similar shock period but which had undergone splanchnicectomy 14 days earlier. In all animals a stimulated gastric secretion test was performed three days before and eight days after splanchnicectomy. All animals in the control group showed severe gastric mucosal lesions after shock. Conversely, the piglets with splanchnicectomy developed no changes (five animals) or only minor changes (two animals). The efficacy of splanchnicectomy was confirmed by a stimulated gastric secretion test in which basal acid output did not change after operation, but peak acid output increased significantly. This study suggests that gastric splanchnicectomy prevents gastric ulceration following experimental shock.
将15只小型猪放血至平均主动脉血压为40毫米汞柱，并维持该水平3小时。对照组由8只休克3小时的动物组成，而试验组由7只休克时间相似但在14天前接受了内脏切除术的动物组成。在所有动物中，在内脏切除术前3天和术后8天进行了刺激胃液分泌试验。对照组所有动物在休克后均出现严重的胃黏膜损伤。相反，接受内脏切除术的仔猪未出现变化（5只动物）或仅出现轻微变化（2只动物）。通过刺激胃液分泌试验证实了内脏切除术的效果，其中基础胃酸分泌量术后未改变，但最大胃酸分泌量显著增加。本研究表明，胃内脏切除术可预防实验性休克后的胃溃疡形成。
