Ahmed N, Christou N
Department of Surgery, McGill University, Montreal, Quebec, Canada.
Shock. 1996;6 Suppl 1:S39-42.
The interaction between immune and endothelial cells has become an area of intense research interest over the last several years. These efforts have been spurred by the identification of specific cell adhesion molecules (CAMs) that mediate the interactions between these two cell populations. Recent efforts have focused on further defining the exact function of these CAMs in health and disease. We have focused our efforts on quantification of these CAMs and understanding how their expression relates to neutrophil and endothelial cell function in the setting of the systemic inflammatory response and multiple organ dysfunction syndrome. Theories regarding neutrophil and endothelial cell interactions in the pathogenesis of the systemic inflammatory response syndrome are presented.
在过去几年中，免疫细胞与内皮细胞之间的相互作用已成为一个备受关注的深入研究领域。对特定细胞黏附分子（CAMs）的识别推动了这些研究工作，这些分子介导了这两类细胞群体之间的相互作用。最近的研究致力于进一步明确这些CAMs在健康和疾病中的具体功能。我们的研究重点是对这些CAMs进行定量分析，并了解它们的表达如何与全身炎症反应和多器官功能障碍综合征背景下的中性粒细胞及内皮细胞功能相关。本文还介绍了关于全身炎症反应综合征发病机制中中性粒细胞与内皮细胞相互作用的理论。
