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Can Fam Physician. 1996 Sep;42:1769-78.
2
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Cocaine abuse sharply reduced in an effective methadone maintenance program.在一个有效的美沙酮维持治疗项目中，可卡因滥用现象大幅减少。
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Cost and cost-effectiveness of standard methadone maintenance treatment compared to enriched 180-day methadone detoxification.与强化180天美沙酮脱毒治疗相比，标准美沙酮维持治疗的成本及成本效益
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本文引用的文献

1
Dose-response effects of methadone in the treatment of opioid dependence.美沙酮治疗阿片类物质依赖的剂量-效应关系
Ann Intern Med. 1993 Jul 1;119(1):23-7. doi: 10.7326/0003-4819-119-1-199307010-00004.
2
Organic mood syndrome associated with detoxification from methadone maintenance.与美沙酮维持治疗脱毒相关的器质性心境综合征。
Am J Psychiatry. 1993 Mar;150(3):423-8. doi: 10.1176/ajp.150.3.423.
3
Seroprevalence of and risk factors for HIV-1 infection in injection drug users in Montreal and Toronto: a collaborative study.蒙特利尔和多伦多注射吸毒者中HIV-1感染的血清流行率及危险因素：一项合作研究。
CMAJ. 1993 Oct 1;149(7):945-51.
4
The effects of psychosocial services in substance abuse treatment.心理社会服务在药物滥用治疗中的作用。
JAMA. 1993 Apr 21;269(15):1953-9.
5
A follow-up study of heroin addicts five years after first admission to a methadone treatment program.对首次进入美沙酮治疗项目五年后的海洛因成瘾者进行的一项随访研究。
Drug Alcohol Depend. 1980 Nov;6(5):295-313. doi: 10.1016/0376-8716(80)90197-0.
6
The Swedish methadone maintenance program: a controlled study.瑞典美沙酮维持治疗项目：一项对照研究。
Drug Alcohol Depend. 1981 Jun;7(3):249-56. doi: 10.1016/0376-8716(81)90096-x.
7
Treatment for drug abuse. Follow-up outcomes and length of time spent.药物滥用治疗。随访结果及持续时间。
Arch Gen Psychiatry. 1981 Aug;38(8):875-80. doi: 10.1001/archpsyc.1981.01780330033003.
8
Patterns of 1-day and 4-month motor functioning in infants of women on methadone.服用美沙酮的女性所生婴儿1日龄和4月龄时的运动功能模式
Neurobehav Toxicol Teratol. 1982 Jul-Aug;4(4):473-6.
9
Differential motor and state functioning in newborns of women on methadone.母亲服用美沙酮的新生儿的运动和状态功能差异
Neurobehav Toxicol Teratol. 1982 Jul-Aug;4(4):459-62.
10
Polydrug- and methadone-addicted newborns: a continuum of impairment?多药成瘾和美沙酮成瘾的新生儿：存在一系列损害吗？
Pediatrics. 1982 Aug;70(2):210-3.

接受美沙酮治疗的阿片类药物依赖患者。医生应如何管理治疗。

Opiate-dependent patients receiving methadone. How physicians should manage therapy.

作者信息

Kahan M, Sutton N

机构信息

St. Joseph's Health Centre, Toronto.

出版信息

Can Fam Physician. 1996 Sep;42:1769-78.

PMID:8828879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2146884/
Abstract

Methadone treatment can reduce illicit drug use, needle sharing, and the social costs and health risks of heroin addiction. It is superior to no treatment, detoxification, or treatment programs lasting less than 3 months. For most patients, the optimal methadone dose is 50 to 120 mg daily. Supervised, random urine drug specimens should be collected at least twice weekly. Long-term counseling is essential and should include information on the risks of needle sharing and on screening for HIV and hepatitis B and C.

摘要

美沙酮治疗可以减少非法药物使用、共用针头以及海洛因成瘾带来的社会成本和健康风险。它优于不治疗、脱毒治疗或持续时间少于3个月的治疗项目。对于大多数患者来说，美沙酮的最佳剂量是每日50至120毫克。应至少每周两次采集受监督的随机尿液药物样本。长期咨询至关重要，应包括关于共用针头风险以及艾滋病毒和乙型及丙型肝炎筛查的信息。