Citores L, Muñoz R, De Benito F M, Iglesias R, Ferreras J M, Girbes T
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Valladolid, Spain.
Cell Mol Biol (Noisy-le-grand). 1996 Jun;42(4):473-6.
The new type 2 RIPs ebulin l, nigrin b and nigrin f present in Sambucus display toxicity to HELA cells several orders of magnitude lower than that displayed by ricin. Despite N-terminal amino acid homology between the three RIPs in both the A and the B chains, these compounds display very different degrees of toxicity to HELA cells that does not seem to be paralleled by immunologic correlations. It is suggested that small changes in the protein structure are most probably responsible for the different degrees of toxicity.
接骨木中存在的新型2型核糖体失活蛋白（RIPs）——西洋接骨木毒蛋白l、黑接骨木苷b和黑接骨木苷f，对人宫颈癌细胞（HELA细胞）的毒性比蓖麻毒素低几个数量级。尽管这三种RIPs的A链和B链在N端氨基酸上具有同源性，但这些化合物对HELA细胞显示出非常不同程度的毒性，而这种毒性差异似乎与免疫相关性并不平行。研究表明，蛋白质结构的微小变化很可能是造成不同程度毒性的原因。
