Wapnir R A, Teichberg S, Go J T, Wingertzahn M A, Harper R G
Department of Pediatrics, North Shore University Hospital-New York University School of Medicine, Manhasset, USA.
J Am Coll Nutr. 1996 Aug;15(4):377-82. doi: 10.1080/07315724.1996.10718612.
To assess whether the addition of gum arabic (GA) to oral rehydration solutions (ORS) of either 60 or 90 mM sodium enhances net water and sodium absorption in rats.
Perfusion of a jejunal segment of male juvenile rats under anesthesia, and determination of net water and sodium absorption, and unidirectional fluid movements using appropriate markers.
Addition of 5 and 10 g/L of GA increased the rates of sodium removal from the intestinal lumen perfused with ORS containing either 60 or 90 mM sodium. Net water absorption was unaffected, although GA tended to facilitate bidirectional fluid movement. The alteration of solute transport rates by the addition of 10 g/L GA was associated with an expansion of the basolateral intercellular spaces.
A soluble fiber such as GA appears to be an effective enhancer of sodium absorption from ORS when tested in experimental animals. Since GA does not affect viscosity, an alteration of solute diffusibility through the brush border membrane and changes in intercellular compartments may underlie the observed improvement of sodium absorption.
评估在含60 mM或90 mM钠的口服补液盐（ORS）中添加阿拉伯胶（GA）是否能增强大鼠的净水分和钠吸收。
对雄性幼鼠进行麻醉后对空肠段进行灌注，并使用合适的标记物测定净水分和钠吸收以及单向液体流动情况。
添加5 g/L和10 g/L的GA可提高从灌注含60 mM或90 mM钠的ORS的肠腔中去除钠的速率。尽管GA倾向于促进双向液体流动，但净水分吸收未受影响。添加10 g/L GA导致的溶质转运速率改变与基底外侧细胞间间隙的扩大有关。
在实验动物中进行测试时，像GA这样的可溶性纤维似乎是ORS中钠吸收的有效增强剂。由于GA不影响粘度，通过刷状缘膜的溶质扩散性改变和细胞间隔室的变化可能是观察到的钠吸收改善的基础。
