Piérard G E, Piérard-Franchimont C
Department of Dermatopathology, University of Liège, Belgium.
Dermatology. 1996;192(2):116-9. doi: 10.1159/000246333.
The effect of low-dose cyclosporin A (CsA) on psoriatic onychopathy has not yet been thoroughly studied.
To measure the changes in nail surface contours during a 3-mg/kg/day CsA therapy.
In vivo optical profilometry was performed at regular intervals in 5 psoriatic patients to derive mean roughness (Ra) and mean depth of roughness (Rz) values of nails. Segmental Rz served to evaluate long-term onychochronobiology.
Untreated psoriatic trachyonychia was best described by Rz which showed large interindividual differences. A progressive improvement in segmental Rz took place after 2-3 months of maintenance therapy.
CsA improves psoriatic onychopathy after an apparent lag phase. The maximum improvement may only be reached during the CsA tapering phase.
低剂量环孢素A（CsA）对银屑病甲病的影响尚未得到充分研究。
测量在每天3mg/kg CsA治疗期间指甲表面轮廓的变化。
对5例银屑病患者定期进行体内光学轮廓测量，以得出指甲的平均粗糙度（Ra）和平均粗糙度深度（Rz）值。节段性Rz用于评估长期甲生物钟学。
未治疗的银屑病甲营养不良用Rz描述最佳，其个体间差异较大。维持治疗2至3个月后，节段性Rz有进行性改善。
CsA在明显的延迟期后可改善银屑病甲病。最大改善可能仅在CsA减量期达到。
