Klockgether-Radke A, Piorek V, Crozier T, Kettler D
Department of Anaesthesiology, Georg August University of Göttingen, Germany.
Eur J Anaesthesiol. 1996 Jan;13(1):3-9. doi: 10.1097/00003643-199601000-00002.
Sixty ASA I and II patients scheduled for laparoscopic cholecystectomy or inguinal herniotomy were randomly assigned to one of two groups: Group one (n = 30): induction with thiopentone 4-6 mg kg-1, fentanyl 2 micrograms kg-1, pancuronium 0.03 mg kg-1, and succinylcholine 1 mg kg-1, maintainance with halothane (0.8-1.5%), and N2O in O2 (FiO2 = 0.33). Group two (n = 30): induction with propofol 2-3 mg kg-1, fentanyl 2 micrograms kg-1, pancuronium 0.03 mg kg-1, and succinylcholine 1 mg kg-1, maintainance with propofol 6-10 mg kg-1 h-1, and O2 in N2 (FiO2:0.33). Seven of the patients experienced nausea in each group with group one having higher emetic scores. Six patients in group one vomited compared to none in group two (P < 0.05). The overall incidence of emetic sequelae (nausea or vomiting) was 43% in group one and 23% in group two (P = 0.17). Patients with propofol anaesthesia had lower emetic scores and higher recovery scores compared with those after thiopentone/halothane anaesthesia.
六十例计划行腹腔镜胆囊切除术或腹股沟疝修补术的美国麻醉医师协会（ASA）分级为I级和II级的患者被随机分为两组：第一组（n = 30）：诱导使用硫喷妥钠4 - 6 mg/kg、芬太尼2μg/kg、泮库溴铵0.03 mg/kg和琥珀酰胆碱1 mg/kg，维持使用氟烷（0.8 - 1.5%）以及氧气和氧化亚氮混合气（吸入氧分数FiO2 = 0.33）。第二组（n = 30）：诱导使用丙泊酚2 - 3 mg/kg、芬太尼2μg/kg、泮库溴铵0.03 mg/kg和琥珀酰胆碱1 mg/kg，维持使用丙泊酚6 - 10 mg·kg-1·h-1以及氮气和氧气混合气（FiO2:0.33）。每组各有7例患者出现恶心，第一组的呕吐评分更高。第一组有6例患者呕吐，而第二组无呕吐患者（P < 0.05）。第一组恶心或呕吐等呕吐后遗症的总发生率为43%，第二组为23%（P = 0.17）。与硫喷妥钠/氟烷麻醉后的患者相比，丙泊酚麻醉的患者呕吐评分更低，恢复评分更高。
